Selenium

Selenium is primarily known for its role as an essential trace element in the human body, contributing to various physiological processes such as antioxidant defense, thyroid hormone metabolism, and immune function [1]. Research suggests potential benefits for cancer treatment [2]. Studies indicate that selenium can exert diverse effects, which may be advantageous in inhibiting tumor progression and bolstering cancer therapy response [2].

Studies exploring selenium's efficacy in cancer treatment:

• Prostate Cancer: Selenium supplementation demonstrated potential in preventing prostate cancer in clinical trials [10].
• Colorectal Cancer: Selenium-doped nanoparticles exhibited promising results in synergistic therapy against drug-resistant colorectal cancer [11].
• Breast Cancer: Selenium compounds have been investigated for their effects on breast cancer progression and therapy response [12].
• Lung Cancer: Selenium's modulatory effects on immune responses may hold implications for lung cancer treatment and immune checkpoint inhibitors.

Combination therapy with selenium might amplify other cancer treatments:

• Increased Sensitivity to Chemotherapy: Selenium supplementation has shown potential to sensitize cancer cells to chemotherapy, potentially increasing treatment efficacy [7].
• Synergy with Radiotherapy: Selenium's DNA repair and apoptosis-inducing properties could enhance the effects of radiotherapy [8].
• Effect on Tumor Growth: Preliminary findings suggest that selenium supplementation could slow down tumor progression, complementing traditional treatments [6].
• Targeting Specific Cancer Cells: Selenium's ability to modulate immune responses might assist in targeting specific cancer cells and reducing treatment resistance [9].