Resveratrol

Resveratrol is a polyphenolic compound primarily found in grape products such as red wine, celebrated for its antioxidant and anti-inflammatory properties [1],[2]. Despite its controversial application in anti-aging, research suggests that resveratrol holds promise in the realm of cancer therapy [3].

Breast Cancer: Studies suggest that resveratrol prompts cell death in breast cancer, indicating its potential efficacy in inhibiting tumor progression [8],[9].

Colorectal Cancers: Resveratrol may act as an anti-inflammatory, which is a main mechanism for the development of colorectal cancers, and decrease cancer cell survival [10]. 

Nrf2 Signaling Pathway Activation: Resveratrol's ability to activate the Nrf2 signaling pathway presents an avenue for its anti-cancer effects, potentially enhancing apoptosis and inhibiting cancer cell proliferation [5].

Conclusion

Resveratrol's potential in cancer therapy hinges on its multifaceted mechanisms, from antioxidant and anti-inflammatory pathways to sensitizing cancer cells and impacting tumor growth. While promising, further research is needed to address challenges such as bioavailability and potency [11]. Utilizing resveratrol in combination therapies could revolutionize cancer treatment, but more studies and clinical trials are essential for harnessing its full potential.

Resveratrol potential in combination therapy offers various avenues for improving cancer treatment outcomes:

• Increased Sensitivity to Chemotherapy Resveratrol's potential to sensitize cancer cells to chemotherapy treatments enhances their responsiveness and may lead to improved therapeutic outcomes [6].
• Synergy with Targeted Therapies When combined with specific targeted therapies, resveratrol might act as a sensitizer, potentially enhancing the efficacy of the treatment [6].
• Impact on Tumor Growth Resveratrol's ability to decelerate tumor progression may complement other treatments, leading to a comprehensive approach in cancer therapy [6].