Folate

Folate, also known as vitamin B9, is primarily recognized for its essential role in DNA synthesis, cell division, and overall cellular function [1]. It is crucial for maintaining normal cell growth and development, making it a critical nutrient for various physiological processes [1]. Folate deficiency has been linked to an increased risk of neural tube defects, anemia, and other health complications [2]. However, recent research suggests that folate may also have potential benefits in the context of cancer treatment [3].

Studies indicate that folate can modulate various pathways and mechanisms that are relevant to cancer progression and therapy response, making it an intriguing subject for further investigation [3].

Case Studies

• Breast Cancer: Folate-based targeted therapies have demonstrated promise in inhibiting the growth of breast cancer cells [13].

Colorectal Cancer: Folate supplementation has shown potential in enhancing the efficacy of certain chemotherapy regimens in colorectal cancer treatment [14].

• Increased Sensitivity to Chemotherapy: Folate could enhance the sensitivity of cancer cells to specific chemotherapy drugs, potentially lowering drug resistance [10].
• Synergy with Targeted Therapies: Folate might amplify the effects of targeted therapies by enhancing the delivery of drugs to cancer cells [10].
• Effect on Tumor Growth: Preclinical studies indicate that folate supplementation could slow tumor growth, potentially serving as an adjuvant to other treatments [11].
• Targeting Specific Cancer Cells: Folate-conjugated therapies could target specific cancer cell populations, addressing issues of heterogeneity and treatment resistance [12].