D-Mannose

D-Mannose is a naturally occurring sugar that is primarily known for its role in urinary tract health. It is commonly used as a supplement to prevent and treat urinary tract infections (UTIs) by preventing the adhesion of certain bacteria to the urinary tract lining. [1] However, emerging research suggests potential benefits of D-Mannose in cancer treatment. [2] Studies indicate that D-Mannose can modulate various cellular mechanisms, which may be advantageous in inhibiting tumor progression and bolstering cancer therapy response. [2]

• Breast Cancer: Research indicates that D-Mannose can hinder breast cancer cell proliferation, and make the breast cancer cells more sensitive to pro-oxidant treatment. [4]
• Prostate Cancer: D-Mannose's metabolic effects may impact prostate cancer cell growth and survival. [10]
• Colon Cancer: Investigations suggest that D-Mannose might influence the inflammatory microenvironment of colon tumors, preventing their development and progression. [11]
• Pancreatic Cancer: Studies have shown that D-Mannose's immune-modulating effects could have implications for pancreatic cancer treatment. [12]

• Increased Sensitivity to Chemotherapy: Studies suggest D-Mannose may enhance the efficacy of chemotherapy by increasing cancer cell susceptibility. [7]
• Synergy with Immunotherapy: D-Mannose's immune-modulating properties could complement immunotherapeutic approaches, enhancing their impact. [7]
• Effect on Tumor Growth: Preliminary findings propose D-Mannose's ability to slow tumor progression, making it a valuable addition to combination treatments. [8]
• Targeted Drug Delivery: D-Mannose-conjugated drug delivery systems might specifically target cancer cells, improving treatment precision. [9]